A view from the trenches – Anti-malarial drug development
Joseph DeRisi, Professor and Vice Chair, Department of Biochemistry and Biophysics, UCSF & a Howard Hughes Medical Institute Investigator
Development of a drug for human medicine is most often a long and arduous process and the vast majority of efforts ultimately fail. Drug development for human malaria is complicated by the fact that the molecular biology of the parasite is still poorly understood and that target identification and validation has historically been difficult. Yet, there are reasons to be optimistic. In recent years, a new wave of promising compounds has been generated. In this talk, I will describe the development and characterization of SJ733, a new fast-acting preclinical candidate.